U.S. President Barack Obama departs after delivering a statement from Martha's Vineyard, Massachusetts, during his vacation August 20, 2014. Obama on Wednesday condemned the Islamic State militants who beheaded an American journalist as "a cance
U.S. President Barack Obama departs after delivering a statement from Martha's Vineyard, Massachusetts, during his vacation August 20, 2014. Obama on Wednesday condemned the Islamic State militants who beheaded an American journalist as "a cancer" and said "their ideology is bankrupt." "The whole world is appalled by the brutal murder of James Foley," Obama said, speaking a day after the militants released a video of Foley being beheaded. Obama said he called Foley's family to express his condolences. Reuters/Kevin Lamarque

The ISIS has renewed pressure on the U.S., demanding this time $6.6 million as well as the release of Aafia Siddiqui, otherwise it will terminate the life of a captured female American humanitarian aid worker.

This, as reports emerged of a first ever American jihadi dying in Syria fighting alongside extremists, fighting against the superpower. His death further fuels assumptions the radical ISIS jihadis are already within the confines of the U.S. and are just awaiting orders when to strike the superpower.

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The 26-year-old aid worker was kidnapped in Syria in 2013 while doing aid work. Fox News reported the woman hails from the West Coast, while ABC News said she is the third of at least four Americans believed to be imprisoned by the extremist Muslim organization.

In exchange for her life, the Islamic State militants demand the U.S. release Siddiqui, a Pakistani neuroscientist who had been dubbed "most wanted" by the U.S. government in 2004, according to the National Journal. The New York Post had likewise branded her as the "Al-Qaida Mom."

The ISIS had actually demanded her release even in the ransom letter they sent to the family of beheaded American journalist James Foley.

Siddiqui had been convicted in 2010 in the 2008 murder plot of U.S. officials. She was slapped with an 86-year term in federal prison.

Earning a degree in biology from the Massachusetts Institute of Technology and a doctorate in cognitive neuroscience from Brandeis University, Siddiqui reportedly married the nephew of al-Qaida lieutenant Khalid Sheikh Mohammed in 2003.

She is being held at a federal prison in Fort Worth, Texas.

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Siddiqui's family immediately maintained in a letter sent out through supporters that they do not have connections with the ISIS.

"If the issue is true, we would like to state that our family does not have any connections to such groups or actions," a letter written by Siddiqui's family stated.

Mauri Saalakhan of the Peace and Justice Foundation, likewise stressed this is not how the family wishes to have Siddiqui released, if ever she does gets released.

"They're opposed to it. In their letter to ISIS they made it very clear, this is not the way, these are not the conditions under which we want our loved ones released," Saalakhan said. "Nor did they want harm to come to anyone else's loved one in the name of Aafia... They conveyed that message loud and clear."

The family pointed out in the letter that they cannot tolerate a "by any means necessary' approach to Aafia's freedom. Nor can we accept that someone else's daughter or sister suffer like Aafia is suffering."

Meantime, America is now distraught after authorities had confirmed a 33-year-old American had died fighting alongside the terror ISIS group.

Douglas McCain was an African-American from Minneapolis who converted to Islam and eventually signed up with extremist forces in Syria.

According to the Free Syrian Army, McCain was killed I n an internecine militants' fight near Aleppo over the weekend.

His family was devastated of the news, at the same time surprised he was in Syria.

"He was telling all of us he was in Turkey," Kenyata McCain, a cousin, told the Star Tribune. She said it was only last Friday that they last talked.

"I didn't know that he was in support of Isis," she told the newspaper. "I didn't think he would be."