The search for Nancy Guthrie, the 84-year-old mother of NBC "Today" show co-anchor Savannah Guthrie, entered its 41st day Friday with authorities emphasizing that the February abduction from her Tucson-area home appears to have been targeted, though no suspect has been publicly identified.

Pima County Sheriff Chris Nanos provided the latest update Thursday, telling NBC News correspondent Liz Kreutz that investigators believe the home was deliberately selected. "We think it was targeted, but we're not 100% sure," Nanos said in the interview, broadcast on NBC Nightly News. He did not rule out the possibility that the perpetrator could strike again, urging continued public vigilance and tips to the FBI.

Guthrie was last seen around 9:45 p.m. Jan. 31 after dining at her daughter Annie's home. Family members dropped her off, and she was reported missing Feb. 1 when she failed to attend church. Authorities quickly classified the case as an abduction, citing evidence she was taken against her will. Drops of blood were found on her front porch, and her pacemaker reportedly disconnected from monitoring devices shortly after, around 8 minutes past midnight.

Nancy Guthrie
Nancy Guthrie

The investigation, involving the Pima County Sheriff's Office and FBI, has generated thousands of leads. Officials have reviewed extensive video footage — up to 10,000 hours in some reports — from home security systems and nearby cameras. New security images emerged this week showing potential activity near the home, including an armed individual tampering with a front door camera, though details remain limited.

Evidence collected includes a glove fragment with unknown DNA, described as a mixture common in violent crimes, and a gun holster. Investigators are employing investigative genetic genealogy to trace the DNA, with experts like CeCe Moore of Parabon NanoLabs expressing confidence it could lead to identification.

A damaged utility box near the residence, possibly linked to an internet outage around the time of the disappearance, is under review. Cadaver dogs were used early but have been paused as the search shifts focus.

The family has offered a $1 million reward for information leading to Nancy Guthrie's recovery, consistent with FBI guidelines. Savannah Guthrie has made repeated public pleas, including Instagram videos urging anyone with knowledge to contact authorities anonymously at 1-800-CALL-FBI. "Someone knows how to find our mom and bring her home," she said in one post.

Relatives have been ruled out as suspects. No ransom demands have been confirmed, though early speculation included cryptocurrency-related motives tied to other Arizona cases, dismissed by officials.

The case has drawn national attention, with appearances on programs like "America's Most Wanted" and commentary from figures such as Nancy Grace, who vouched for Savannah Guthrie's character and expressed doubt family involvement.

Meanwhile, a separate Nancy Guthrie — a prominent Bible teacher, author and speaker based in Franklin, Tennessee — maintains an active ministry schedule. Her website lists upcoming events, including a March 20-21 appearance at Redeemer Lincoln Square in New York and an April Katoomba Easter Convention in Australia. She is preparing a 2026 devotional book, "Beholding Christ," with related events planned into 2027. No connection exists between the two women beyond the shared name.

As the investigation continues at full speed, with the FBI recently adjusting its command post, officials stress public tips remain crucial. The sheriff reiterated that family members are not suspects and emphasized analyzing lab results, videos and images without disclosing specifics to protect the case.

Friends and church members describe Nancy Guthrie as a beloved, long-time community member who attended services regularly. The prolonged uncertainty has left her family and supporters seeking closure amid hopes for her safe return.