An 18-year-old Mill Park male died in a tragic single vehicle crash, while his female companion is in the hospital over serious head injuries.

Police told AAP the teen driver's car veered off Bonds Road at Lower Plenty and crashed through a fence before rolling several times, about 10.50pm (AEDT) on Monday.

Police suspects the teen driver lost control of his car, causing him to die on the scene.

A police statement noted the driver's lone passenger has been rushed to the Royal Melbourne Hospital with serious head injuries.

The death brings Victoria's road toll to 19, six more than at the same time last year, AAP reported.